Understanding how certain bacteria in the mouth help prevent tooth decay
Pyruvate oxidase: a molecular determinant of commensalism among the oral microbiome
This study is looking at how a helpful enzyme made by good bacteria in your mouth can help stop tooth decay, with the goal of finding better ways to keep your teeth healthy and prevent cavities.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10799548 on NIH RePORTER |
What this research studies
This research investigates the role of a specific enzyme, pyruvate oxidase, produced by beneficial oral bacteria in preventing tooth decay. By focusing on the molecular mechanisms that allow these bacteria to thrive and inhibit harmful species, the study aims to improve current methods of assessing the risk of dental caries. The researchers will analyze how these bacteria generate energy and produce hydrogen peroxide, which can inhibit the growth of decay-causing bacteria. This approach seeks to enhance our understanding of oral health and develop better prevention strategies for dental caries.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at high risk for dental caries, particularly those with a history of tooth decay or poor oral health.
Not a fit: Patients with no history of dental caries or those who maintain excellent oral hygiene may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective prevention strategies for tooth decay, potentially reducing the prevalence of dental caries.
How similar studies have performed: Previous research has shown promise in understanding the role of oral microbiota in dental health, suggesting that this approach could yield significant insights.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Kreth, Jens — Oregon Health & Science University
- Study coordinator: Kreth, Jens
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.