Understanding how certain bacteria contribute to dental caries
Functional amyloid formation in streptococcus mutans
This study is looking at how a bacteria called Streptococcus mutans, which is known to cause cavities, creates special proteins that might help it stick together in groups, and by understanding this better, we hope to find new ways to prevent or treat tooth decay for people who struggle with it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11142875 on NIH RePORTER |
What this research studies
This research investigates the role of Streptococcus mutans, a bacterium linked to dental caries, in forming functional amyloids that may influence biofilm development. By studying the structural properties of these amyloids and their interactions with other bacterial components, the research aims to uncover new insights into the mechanisms behind dental decay. The approach includes advanced techniques like X-ray fiber diffraction to analyze the amyloid structures and their effects on bacterial behavior in biofilms. This could lead to a better understanding of how to prevent or treat dental caries in affected populations.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and adolescents who are at risk for or currently experiencing dental caries.
Not a fit: Patients with dental caries caused by non-bacterial factors or those who do not have Streptococcus mutans may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating dental caries, particularly in children.
How similar studies have performed: Previous research has shown success in understanding the role of amyloids in other microbial contexts, suggesting potential for breakthroughs in this area as well.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Brady, L. Jeannine — University of Florida
- Study coordinator: Brady, L. Jeannine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.