Understanding how certain bacteria cause worse eye infections
Rise of lasR mutant Pseudomonas aeruginosa keratitis
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-10880616
This study is looking at how certain mutated strains of a common bacteria, Pseudomonas aeruginosa, affect serious eye infections called keratitis, with the goal of finding better ways to treat people who are dealing with these infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-10880616 on ClinicalTrials.gov |
What this research studies
This research investigates the impact of lasR mutant strains of Pseudomonas aeruginosa on keratitis, a serious eye infection that can lead to vision loss. By analyzing bacterial isolates from a large repository, the study aims to uncover the mechanisms that make these mutants more harmful compared to their wild-type counterparts. The research will involve laboratory experiments to characterize the genetic factors that contribute to the increased virulence of these bacteria, ultimately seeking to inform better treatment strategies for patients suffering from eye infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing keratitis or other severe eye infections caused by Pseudomonas aeruginosa.
Not a fit: Patients with eye infections caused by other types of bacteria or those not affected by keratitis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that prevent vision loss from bacterial eye infections.
How similar studies have performed: Previous research has indicated that understanding bacterial mechanisms can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHANKS, ROBERT M — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: SHANKS, ROBERT M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.