Understanding how certain bacteria cause severe infections in young and immunocompromised mice
Deciphering the pathogenesis of an enteric pathogen in neonatal and immunodeficient mice
This study is looking at how certain bacteria can make young or weakened mice very sick, which helps us learn more about similar infections in people, especially how our immune system and antibodies work to fight these germs.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11088896 on NIH RePORTER |
What this research studies
This research investigates how specific bacteria, such as Citrobacter rodentium and Salmonella enterica, cause severe infections in neonatal and immunocompromised mice, which can help us understand similar infections in humans. By using advanced mouse models that mimic human conditions, the researchers aim to identify the factors that lead to severe disease and how the immune system responds to these infections. The study will explore the role of antibodies in protecting against these pathogens and how the body can fight infections even when certain immune responses are absent.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old and adults with weakened immune systems who are at risk for severe bacterial infections.
Not a fit: Patients who are healthy and have a fully functioning immune system may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and preventive strategies for infectious diarrhea in vulnerable populations, including children and immunocompromised individuals.
How similar studies have performed: Previous research has shown success in using animal models to study infectious diseases, indicating that this approach has the potential to yield valuable insights.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Caballero Flores, Gustavo — University of Wisconsin-Madison
- Study coordinator: Caballero Flores, Gustavo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.