Understanding how certain bacteria break down mucus in the gut
Official title: Genetics Core for Mucin Degrading Bacteria
Funded at Beckman Research Institute/city of Hope · NIH-10935663 · Data updated 2026-11-12
This study is looking at how certain bacteria in your gut break down mucus, which is important for keeping your intestines healthy, especially for people who have had stem cell transplants.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project start | September 21, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $123,249 |
| NIH project number | 1P01HL170046-01A1 |
| Project ID | NIH-10935663 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients undergoing hematopoietic stem cell transplants or those experiencing gastrointestinal issues related to mucus degradation.
✕Less likely to help
Patients with conditions unrelated to gastrointestinal health or those not undergoing treatments affecting the gut microbiome may not benefit from this research.
What this research studies
This research focuses on the intestinal microbiota, specifically bacteria that can degrade mucins, which are vital components of the intestinal mucus layer. It aims to investigate the mechanisms and regulation of mucin degradation by bacteria such as Akkermansia and Bacteroides. The research will involve generating bacterial mutants, conducting high-throughput genetic screens, and analyzing mucin degradation using advanced techniques. By understanding these processes, the research hopes to shed light on health issues related to mucus erosion, particularly in patients undergoing hematopoietic stem cell transplants.
Why it matters
Potential benefit: If successful, this research could lead to improved health outcomes for patients by enhancing our understanding of gut microbiota and its role in maintaining intestinal health.
How similar studies have gone: Previous research has shown promising results in understanding the role of gut microbiota in health, indicating that this approach has potential for success.
Where this research is happening
-
Beckman Research Institute/city of Hope
Duarte, United States Active
Researchers
- Principal investigator: Davey, Lauren Elizabeth — Beckman Research Institute/city of Hope
- Study coordinator: Davey, Lauren Elizabeth
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.