Understanding how certain bacteria become dominant in infections
Official title: Molecular mechanisms for clinical dominance of P. aeruginosa ST111 isolates
Funded at Rice University · NIH-11101129 · Data updated 2026-11-12
This study is looking at how a specific type of bacteria, which can cause serious infections in people with weakened immune systems, is able to resist common antibiotics, so we can find better ways to treat those infections.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rice University NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | June 1, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $187,260 |
| NIH project number | 5R21AI176089-02 |
| Project ID | NIH-11101129 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are immunocompromised patients, particularly those with hematologic malignancies or those recovering from hematopoietic stem cell transplantation.
✕Less likely to help
Patients who are not immunocompromised or do not have a history of hematologic malignancies may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms that allow Pseudomonas aeruginosa ST111 isolates to dominate bloodstream infections, particularly in immunocompromised patients such as those with hematologic malignancies or recovering from stem cell transplants. The study aims to identify the factors contributing to the resistance of these bacteria to common antibiotics, which can lead to severe complications. By analyzing the genetic and biological characteristics of these bacterial strains, the research seeks to fill a critical knowledge gap that could inform better treatment strategies for affected patients.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and better management of infections caused by antibiotic-resistant bacteria in vulnerable patient populations.
How similar studies have gone: Previous research has shown success in understanding antibiotic resistance mechanisms in other bacterial strains, indicating that this approach may yield valuable insights.
Where this research is happening
-
Rice University
Houston, United States Active
Researchers
- Principal investigator: Kirienko, Natasha — Rice University
- Study coordinator: Kirienko, Natasha
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.