Understanding how certain bacteria affect the reproduction of their host species
Official title: The Molecular Mechanism of a Male Killing Gene
Funded at Pennsylvania State University, the · NIH-11101666 · Data updated 2026-11-12
This study looks at how a type of bacteria called Wolbachia, passed down from mother to offspring, affects the reproduction of certain bugs by causing them to have fewer male babies, and it aims to understand how this happens so we can use this knowledge to help control pest populations.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State University, the NIH-funded |
| Lab location | 1 site (University Park, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $600,618 |
| NIH project number | 1R01AI189624-01 |
| Project ID | NIH-11101666 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals involved in agriculture or public health sectors dealing with arthropod-borne diseases.
✕Less likely to help
Patients who are not affected by or do not interact with arthropod-borne diseases may not receive any benefit from this research.
What this research studies
This research investigates how maternally-inherited bacteria, specifically Wolbachia, influence the reproductive biology of arthropods by selectively killing male offspring. The study aims to uncover the molecular mechanisms behind this male killing phenomenon, which enhances the reproductive success of infected females. By analyzing gene expression and the interactions between these bacteria and their hosts, the research seeks to provide insights into the ecological and evolutionary implications of this relationship. The findings could have significant applications in pest control strategies, particularly in reducing populations of harmful arthropods.
Why it matters
Potential benefit: If successful, this research could lead to innovative pest control methods that reduce populations of disease-carrying arthropods.
How similar studies have gone: Previous research has shown success in using similar bacterial strategies for pest control, indicating potential for impactful findings in this study.
Where this research is happening
-
Pennsylvania State University, the
University Park, United States Active
Researchers
- Principal investigator: Bordenstein, Seth R — Pennsylvania State University, the
- Study coordinator: Bordenstein, Seth R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.