Understanding how certain bacteria affect the human mouth's ecosystem
Official title: Determining the mechanism and impact of streptococcal RaS-RiPPs on the human oral microbiome
Funded at Iowa State University · NIH-11174931 · Data updated 2026-11-12
This study is looking at how certain bacteria in your mouth, especially Streptococci, affect your oral health by producing special compounds that can help or harm other bacteria, with the hope of finding new ways to prevent or treat dental issues like cavities.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Iowa State University NIH-funded |
| Lab location | 1 site (Ames, United States) |
| Project start | August 16, 2024 |
| Project end | August 15, 2027 |
| Funding year | 2024 |
| Award (this year) | $249,000 |
| NIH project number | 4R00DE032311-02 |
| Project ID | NIH-11174931 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing dental caries or other oral health problems related to bacterial imbalances.
✕Less likely to help
Patients without any oral health issues or those not affected by Streptococci-related conditions may not benefit from this research.
What this research studies
This research investigates the role of specific bacteria, particularly Streptococci, in the human oral microbiome and their impact on oral health. It focuses on understanding how these bacteria produce unique compounds that can influence the growth of other bacteria and the overall health of the mouth. By studying the mechanisms of action of these compounds, the research aims to uncover their biological significance and potential effects on conditions like dental caries. Patients may benefit from insights that could lead to new treatments or preventive measures for oral diseases.
Why it matters
Potential benefit: If successful, this research could lead to innovative strategies for preventing and treating dental caries and other oral health issues.
How similar studies have gone: Previous research has shown promise in understanding the role of oral bacteria in health and disease, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Iowa State University
Ames, United States Active
Researchers
- Principal investigator: Rued, Britta — Iowa State University
- Study coordinator: Rued, Britta
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.