Understanding how certain bacteria affect gut health after stem cell transplants
Official title: Administrative, biospecimen and biostatistical core
Funded at Beckman Research Institute/city of Hope · NIH-10935662 · Data updated 2026-11-12
This study is looking at how certain bacteria in the gut might make side effects worse for patients undergoing stem cell transplants, and it aims to find new ways to help prevent these issues, so if you're a patient in this situation, your participation could help improve future treatments.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project start | September 21, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $541,994 |
| NIH project number | 1P01HL170046-01A1 |
| Project ID | NIH-10935662 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients who are undergoing or have undergone hematopoietic stem cell transplantation.
✕Less likely to help
Patients who are not undergoing stem cell transplants or do not have related gastrointestinal complications may not benefit from this research.
What this research studies
This research focuses on the role of mucin-degrading intestinal bacteria in exacerbating toxicities related to hematopoietic stem cell transplantation (HCT). It aims to collect patient biospecimens and clinical data to support the development of novel therapeutic strategies that could mitigate intestinal graft-versus-host disease (GVHD). The project will involve collaboration among various experts to ensure effective communication and management of the research activities. Patients may be involved in clinical interventional studies that evaluate these new strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that reduce intestinal complications for patients undergoing stem cell transplants.
How similar studies have gone: Previous research has shown promise in targeting gut bacteria to improve outcomes in transplant patients, indicating that this approach may be effective.
Where this research is happening
-
Beckman Research Institute/city of Hope
Duarte, United States Active
Researchers
- Principal investigator: Jenq, Robert — Beckman Research Institute/city of Hope
- Study coordinator: Jenq, Robert
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.