Understanding how certain bacteria adapt to their environments using a specific signaling pathway
Cyclic di-AMP-dependent signaling in tickborne relapsing fever Borrelia
['FUNDING_R01'] · UNIV OF ARKANSAS FOR MED SCIS · NIH-10894203
This study looks at how a specific signaling pathway helps tickborne relapsing fever bacteria survive in different places, like ticks and humans, and by understanding these changes, we hope to find better ways to treat the diseases they cause.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF ARKANSAS FOR MED SCIS (nih funded) |
| Locations | 1 site (LITTLE ROCK, UNITED STATES) |
| Trial ID | NIH-10894203 on ClinicalTrials.gov |
What this research studies
This research investigates how the signaling pathway involving cyclic di-AMP helps tickborne relapsing fever bacteria adapt to different environments, such as those found in ticks and humans. By studying the genetic changes these bacteria undergo, the research aims to uncover important aspects of their survival and pathogenicity. The approach involves inactivating specific components of the signaling pathway to observe the effects on bacterial behavior and adaptation. This could lead to a better understanding of how these bacteria cause disease and how they might be targeted for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been diagnosed with tickborne relapsing fever or are at high risk of exposure to the disease.
Not a fit: Patients who do not have tickborne relapsing fever or related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating tickborne relapsing fever and potentially Lyme disease.
How similar studies have performed: Other research has shown success in understanding bacterial signaling pathways, suggesting that this approach could yield valuable insights.
Where this research is happening
LITTLE ROCK, UNITED STATES
- UNIV OF ARKANSAS FOR MED SCIS — LITTLE ROCK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BLEVINS, JON SCOTT — UNIV OF ARKANSAS FOR MED SCIS
- Study coordinator: BLEVINS, JON SCOTT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.