Understanding how certain B cells affect skin inflammation
Official title: The role of CXCL10 expressing B cells in skin inflammation
Funded at Thomas Jefferson University · NIH-11109473 · Data updated 2026-11-12
This study is looking at how certain immune cells called regulatory B cells help control skin inflammation in conditions like psoriasis and allergic contact dermatitis, and it aims to find new ways to treat these skin issues by understanding how these cells interact with other immune cells.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | June 6, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $234,000 |
| NIH project number | 5R21AI182763-02 |
| Project ID | NIH-11109473 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from inflammatory skin diseases such as psoriasis or allergic contact dermatitis.
✕Less likely to help
Patients with non-inflammatory skin conditions or those not affected by skin diseases may not benefit from this research.
What this research studies
This research investigates the role of regulatory B cells in managing skin inflammation, particularly in conditions like psoriasis and allergic contact dermatitis. It focuses on how these B cells produce a molecule called CXCL10, which may influence the behavior of T cells involved in inflammation. By using a mouse model, the researchers aim to understand the mechanisms by which B cells interact with T cells to either suppress or enhance inflammatory responses. This could lead to new strategies for treating inflammatory skin diseases.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better control skin inflammation and improve the quality of life for patients with inflammatory skin conditions.
How similar studies have gone: Previous research has shown promising results in understanding the role of B cells in inflammation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Thomas Jefferson University
Philadelphia, United States Active
Researchers
- Principal investigator: Debes, Gudrun Philomena — Thomas Jefferson University
- Study coordinator: Debes, Gudrun Philomena
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.