Understanding how certain B cells affect immune responses in organ transplants
Proinflammatory B Cells Defined by TIM-4 in the Alloimmune Response
This study is looking at how different kinds of B cells in your immune system affect organ transplants and treatments, with the goal of finding better ways to help people who have received transplants or have autoimmune diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11118925 on NIH RePORTER |
What this research studies
This research investigates the roles of different types of B cells in the immune response, particularly focusing on proinflammatory B cells and regulatory B cells. It aims to understand how these cells influence the rejection of transplanted organs and the effectiveness of treatments like anti-CD20. By identifying specific markers for these B cells, the researchers hope to develop targeted therapies that can improve transplant outcomes and manage autoimmune diseases. The study will utilize advanced techniques to analyze B cell behavior in various clinical settings.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients undergoing organ transplants or those with autoimmune diseases.
Not a fit: Patients who are not undergoing transplantation or do not have autoimmune conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing organ rejection and enhancing the success of transplants.
How similar studies have performed: Previous research has shown that targeting specific immune cells can lead to significant improvements in treatment outcomes, suggesting a promising avenue for this approach.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Rothstein, David M — University of Pittsburgh at Pittsburgh
- Study coordinator: Rothstein, David M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.