Understanding how certain B cells affect immune responses in organ transplants
Official title: Proinflammatory B Cells Defined by TIM-4 in the Alloimmune Response
Funded at University of Pittsburgh at Pittsburgh · NIH-11118925 · Data updated 2026-11-12
This study is looking at how different kinds of B cells in your immune system affect organ transplants and treatments, with the goal of finding better ways to help people who have received transplants or have autoimmune diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | June 17, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $669,277 |
| NIH project number | 5R01AI184980-02 |
| Project ID | NIH-11118925 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients undergoing organ transplants or those with autoimmune diseases.
✕Less likely to help
Patients who are not undergoing transplantation or do not have autoimmune conditions may not benefit from this research.
What this research studies
This research investigates the roles of different types of B cells in the immune response, particularly focusing on proinflammatory B cells and regulatory B cells. It aims to understand how these cells influence the rejection of transplanted organs and the effectiveness of treatments like anti-CD20. By identifying specific markers for these B cells, the researchers hope to develop targeted therapies that can improve transplant outcomes and manage autoimmune diseases. The study will utilize advanced techniques to analyze B cell behavior in various clinical settings.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing organ rejection and enhancing the success of transplants.
How similar studies have gone: Previous research has shown that targeting specific immune cells can lead to significant improvements in treatment outcomes, suggesting a promising avenue for this approach.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Rothstein, David M — University of Pittsburgh at Pittsburgh
- Study coordinator: Rothstein, David M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.