Understanding how certain antibodies can protect against HIV
Assessing ADCC and Fc-mediated Protection against HIV
['FUNDING_R01'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-10671615
This study is looking at how certain antibodies in the body can help protect against HIV-1 infection, focusing on a specific immune response called ADCC, and it's aimed at finding better ways to measure this response and understand which antibodies might be helpful in creating an effective HIV vaccine.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-10671615 on ClinicalTrials.gov |
What this research studies
This research investigates the role of non-neutralizing antibodies in protecting against HIV-1 infection, focusing on a specific immune response known as antibody-dependent cellular cytotoxicity (ADCC). The team aims to improve methods for measuring ADCC and to explore the specific antibodies that may contribute to protection, using a nonhuman primate model. By examining how viral and cellular factors influence the effectiveness of these antibodies, the research seeks to clarify the immune mechanisms that could lead to a successful HIV vaccine.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at high risk for HIV infection who may benefit from improved vaccine strategies.
Not a fit: Patients who are already HIV-positive or those with advanced AIDS may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective vaccines against HIV, potentially reducing the risk of infection for many individuals.
How similar studies have performed: Previous studies have shown promise in understanding the role of non-neutralizing antibodies in HIV protection, but this specific approach is still being explored.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: EVANS, DAVID T — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: EVANS, DAVID T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immuno-Deficiency Syndrome, Acquired Immunologic Deficiency Syndrome, Acquired Immunodeficiency Syndrome