Understanding how certain antibodies are linked to rheumatoid arthritis
Insights into the origin of ACPAs in RA
This study is looking into how certain antibodies related to rheumatoid arthritis might come from another type of antibody that targets modified proteins, to help us better understand what causes this condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11039460 on NIH RePORTER |
What this research studies
This research investigates the origins of anti-citrullinated protein antibodies (ACPAs), which are closely associated with rheumatoid arthritis (RA). The study aims to explore whether these antibodies arise from a different type of antibody that targets carbamylated proteins. By analyzing monoclonal ACPAs derived from RA patients, the researchers hope to uncover the mechanisms that make citrullinated proteins immunogenic. This could provide valuable insights into the development of RA and its underlying causes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with rheumatoid arthritis who have elevated levels of anti-citrullinated protein antibodies.
Not a fit: Patients without rheumatoid arthritis or those who do not have detectable levels of ACPAs may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of rheumatoid arthritis and potentially new strategies for prevention or treatment.
How similar studies have performed: Previous research has shown promising results in understanding antibody responses in autoimmune diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Andrade, Felipe — Johns Hopkins University
- Study coordinator: Andrade, Felipe
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.