Understanding how certain antibodies are formed and function in the body
Investigating polymeric antibody assembly, structure, function and therapeutic potential
This study is looking at how special antibodies called polymeric immunoglobulins work in our body's mucosal tissues, like those in our gut and lungs, to help fight off germs, and it aims to find ways to use this knowledge to create better treatments for related health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Urbana-Champaign NIH-funded |
| Lab location | 1 site (Champaign, United States) |
| Project ID | NIH-10896262 on NIH RePORTER |
What this research studies
This research investigates the assembly mechanisms and functions of polymeric immunoglobulins (pIgs), which are a type of antibody found in the mucosal tissues of vertebrates. By examining how these antibodies are structured and how they interact with pathogens, the research aims to uncover their unique roles in immune responses. The study employs advanced techniques like cryo-electron microscopy to visualize these antibodies at a molecular level, providing insights into their assembly and function. This knowledge could lead to improved therapeutic strategies for diseases related to mucosal immunity.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions affecting mucosal immunity or those who are at risk of infections related to mucosal surfaces.
Not a fit: Patients with non-mucosal related immune disorders may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of immune responses and lead to better treatments for infections and diseases related to mucosal immunity.
How similar studies have performed: Previous research has shown success in understanding antibody structures and functions, but this specific focus on polymeric immunoglobulins is relatively novel.
Where this research is happening
Champaign, United States
- University of Illinois at Urbana-Champaign — Champaign, United States (Active)
Researchers
- Principal investigator: Stadtmueller, Beth M. — University of Illinois at Urbana-Champaign
- Study coordinator: Stadtmueller, Beth M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.