Understanding how certain antibiotics affect hearing in cystic fibrosis patients
Prevention of Ototoxicity with Effective Monitoring (POEM) Pharmacokinetic and Auditory Linkages
This study is looking at how certain antibiotics used to treat cystic fibrosis might affect hearing, and it aims to find ways to protect patients from hearing loss while they receive these important medications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10907704 on NIH RePORTER |
What this research studies
This research investigates the impact of aminoglycoside antibiotics on hearing function in patients with cystic fibrosis, who are at risk of hearing loss due to these life-saving medications. The study aims to identify individual susceptibility to ototoxicity by measuring drug exposure and using advanced auditory tests to monitor hearing changes. By developing improved monitoring protocols, the research seeks to prevent permanent hearing loss in these patients. Participants will include cystic fibrosis patients receiving aminoglycoside treatments and a control group for comparison.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with cystic fibrosis who are being treated with aminoglycoside antibiotics.
Not a fit: Patients who are not receiving aminoglycoside antibiotics or do not have cystic fibrosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better monitoring and prevention strategies for hearing loss in patients treated with aminoglycoside antibiotics.
How similar studies have performed: Previous research has shown promise in using advanced auditory tests to detect ototoxicity, making this approach both relevant and potentially impactful.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Hunter, Lisa Leigh — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Hunter, Lisa Leigh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.