Understanding how cerebrospinal fluid affects brain development in infants with Down Syndrome.
The Role of CSF Dynamics in Infant Brain and Behavioral Development in Down Syndrome and Related Neurodevelopmental Disorders
This study is looking at how the fluid around the brain affects the growth and development of babies with Down Syndrome and similar conditions, to help find ways to support their brain health as they grow.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11242628 on NIH RePORTER |
What this research studies
This research investigates the role of cerebrospinal fluid (CSF) dynamics in the brain development of infants, particularly those with Down Syndrome and related neurodevelopmental disorders. By utilizing advanced neuroimaging techniques and clinical assessments, the study aims to identify early signs of brain pathology during critical growth periods. The goal is to enhance our understanding of how CSF flow impacts brain health and to develop targeted interventions that could improve outcomes for affected children.
Who could benefit from this research
Good fit: Ideal candidates for this research are infants diagnosed with Down Syndrome or related neurodevelopmental disorders.
Not a fit: Patients without neurodevelopmental disorders or those outside the infant age range may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved early interventions for infants with Down Syndrome, potentially reducing the risk of developing early-onset Alzheimer's disease.
How similar studies have performed: While research on CSF dynamics in adults has shown promising results, this approach in infants with neurodevelopmental disorders is relatively novel and untested.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Garic, Dea — Univ of North Carolina Chapel Hill
- Study coordinator: Garic, Dea
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.