Understanding how cerebrospinal fluid affects brain development in infants with Down Syndrome.
The Role of CSF Dynamics in Infant Brain and Behavioral Development in Down Syndrome and Related Neurodevelopmental Disorders
['FUNDING_CAREER'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-10906946
This study is looking at how the fluid around the brain affects the development of babies with Down Syndrome and similar conditions, hoping to find early signs of any issues so that we can help these children grow healthier.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-10906946 on ClinicalTrials.gov |
What this research studies
This research investigates the role of cerebrospinal fluid (CSF) dynamics in the brain development of infants, particularly those with Down Syndrome and related neurodevelopmental disorders. By utilizing advanced neuroimaging techniques and clinical assessments, the study aims to identify early signs of brain pathology during critical growth periods in infancy. The goal is to understand how CSF flow impacts brain health and to develop targeted interventions that could improve outcomes for affected children.
Who could benefit from this research
Good fit: Ideal candidates for this research are infants diagnosed with Down Syndrome or related neurodevelopmental disorders.
Not a fit: Patients who are older than infancy or do not have neurodevelopmental disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier interventions that significantly improve cognitive and behavioral outcomes for infants with Down Syndrome.
How similar studies have performed: While research on CSF dynamics in adults has shown promising results, this approach in infants with neurodevelopmental disorders is relatively novel and untested.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GARIC, DEA — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: GARIC, DEA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia