Understanding how cerebrospinal fluid affects aging and Alzheimer's disease
Official title: Investigating the role of CSF production and circulation in aging and Alzheimer's disease
Funded at University of Cincinnati · NIH-11261854 · Data updated 2026-11-12
This study is looking at how a special fluid in the brain, called cerebrospinal fluid, affects brain health as we age and in conditions like Alzheimer's, and it's for anyone interested in understanding how we might improve memory and thinking skills in older adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | August 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $207,580 |
| NIH project number | 3R01AG083164-03S1 |
| Project ID | NIH-11261854 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults over 21 years old who are experiencing cognitive decline or are at risk for Alzheimer's disease.
✕Less likely to help
Patients with non-neurological conditions or those under 21 years old may not benefit from this research.
What this research studies
This research investigates the role of cerebrospinal fluid (CSF) and the choroid plexus in brain health, particularly as it relates to aging and Alzheimer's disease. The team will catalog molecules in the CSF system and explore how these molecules influence brain development and immune interactions. By using a special mouse model, they aim to understand how CSF production impacts cognitive function and may help reverse age-related cognitive decline. The findings could provide insights into new therapeutic approaches for age-related brain disorders.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function in aging individuals and those with Alzheimer's disease.
How similar studies have gone: Previous studies have shown promising results in animal models regarding the role of CSF in cognitive health, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Luo, Yu — University of Cincinnati
- Study coordinator: Luo, Yu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.