Understanding how cerebellar nuclei dysfunction affects movement in Spinocerebellar Ataxia Type 1
Official title: Cerebellar Nuclei Dysfunction in Spinocerebellar Ataxia Type 1
Funded at University of Minnesota · NIH-11056262 · Data updated 2026-11-12
This study is looking at how certain parts of the brain called cerebellar nuclei affect movement problems in people with Spinocerebellar Ataxia Type 1 (SCA1), hoping to find new ways to help improve balance and walking for those living with this condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | September 20, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $423,500 |
| NIH project number | 1R21NS136962-01A1 |
| Project ID | NIH-11056262 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Spinocerebellar Ataxia Type 1 who experience motor coordination issues.
✕Less likely to help
Patients with other forms of ataxia or those without a diagnosis of Spinocerebellar Ataxia Type 1 may not benefit from this research.
What this research studies
This research investigates the role of cerebellar nuclei in Spinocerebellar Ataxia Type 1 (SCA1), a genetic neurodegenerative disorder. It aims to understand how the dysfunction of these nuclei contributes to the motor deficits experienced by patients, such as balance and gait issues. By studying the effects of the mutant ATXN1 gene on cerebellar nuclei function, the research seeks to uncover the underlying mechanisms of disease progression. The findings could lead to new insights into potential therapeutic targets for SCA1 and similar conditions.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective therapies for patients suffering from Spinocerebellar Ataxia Type 1.
How similar studies have gone: While this research explores a relatively novel area regarding cerebellar nuclei dysfunction in SCA1, similar studies in other neurodegenerative conditions have shown promising results.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Cvetanovic, Marija — University of Minnesota
- Study coordinator: Cvetanovic, Marija
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.