Understanding how cerebellar circuits affect thinking and emotional responses
Recruitment of Cerebellar Circuits to Modulate Cognition, Reward and Avoidance of Threat
This study is looking at how certain parts of the brain help with thinking and memory, especially for people with conditions like PTSD and brain injuries, to find new ways to improve their cognitive abilities.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Puget Sound Healthcare System NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11098426 on NIH RePORTER |
What this research studies
This research investigates the role of specific brain regions in the cerebellum that are activated during complex cognitive tasks. It aims to understand how these circuits influence cognitive functions such as attention and memory, particularly in individuals with psychiatric disorders like PTSD and TBI. By studying both human and non-human primate models, the research seeks to uncover the anatomical and functional organization of these brain areas, which could lead to targeted therapies for cognitive impairments. The findings may provide insights into how dopamine signaling affects cognition and emotional responses.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults with psychiatric conditions such as PTSD or traumatic brain injury who experience cognitive difficulties.
Not a fit: Patients without psychiatric disorders or cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic options for patients with cognitive impairments related to psychiatric disorders.
How similar studies have performed: Previous research has shown promising results in understanding the role of cerebellar circuits in cognition, suggesting that this approach may lead to significant advancements in treatment.
Where this research is happening
Seattle, United States
- VA Puget Sound Healthcare System — Seattle, United States (Active)
Researchers
- Principal investigator: Carlson, Erik Sean — VA Puget Sound Healthcare System
- Study coordinator: Carlson, Erik Sean
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.