Understanding how centrosomes mature in vertebrates
Mechanism of centrosome maturation in vertebrates
['FUNDING_R01'] · SYRACUSE UNIVERSITY · NIH-11001188
This study looks at how a protein called pericentrin helps build a part of our cells called the centrosome, which is important for making sure our chromosomes divide correctly, and it hopes to uncover information that could help people with developmental disorders related to problems in this process.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SYRACUSE UNIVERSITY (nih funded) |
| Locations | 1 site (SYRACUSE, UNITED STATES) |
| Trial ID | NIH-11001188 on ClinicalTrials.gov |
What this research studies
This research investigates the process of centrosome maturation, which is essential for proper chromosome segregation during cell division. It focuses on the role of a protein called pericentrin in assembling the centrosome's structure, which is crucial for organizing microtubules. By exploring how this protein and others contribute to centrosome function, the research aims to fill gaps in our understanding of cellular processes that can lead to developmental disorders. Patients may benefit from insights gained about conditions linked to centrosome dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with developmental disorders such as primordial dwarfism, microcephaly, or Down syndrome.
Not a fit: Patients with conditions unrelated to centrosome function or those not experiencing developmental disorders may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for developmental disorders associated with centrosome dysfunction.
How similar studies have performed: While the specific mechanisms of centrosome maturation are still being explored, related research has shown promise in understanding cellular processes that impact developmental disorders.
Where this research is happening
SYRACUSE, UNITED STATES
- SYRACUSE UNIVERSITY — SYRACUSE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JAO, LI-EN — SYRACUSE UNIVERSITY
- Study coordinator: JAO, LI-EN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: birdlike face syndrome, Cancers