Understanding how centrosomes function in cell division and development
Molecular, material, and structural design principles of centrosomes
This study is looking at how tiny structures in our cells, called centrosomes, help cells divide properly during early development, and it aims to understand how their size and function are affected by physical forces, which could help us learn more about certain developmental disorders and cancers.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10890095 on NIH RePORTER |
What this research studies
This research investigates the role of centrosomes, which are crucial for organizing microtubules and ensuring proper cell division during early development. The study aims to uncover the molecular mechanisms that determine the size and functionality of centrosomes, particularly how they respond to physical forces. Using innovative techniques like cryo-electron tomography and nano-rheology, researchers will analyze the structural properties of centrosomes in living embryos. This work could provide insights into various developmental disorders and cancers linked to centrosome dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with developmental disorders or cancers that may be linked to centrosome dysfunction.
Not a fit: Patients with conditions unrelated to centrosome function or those who do not have developmental disorders or cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing and treating developmental disorders and cancers associated with centrosome abnormalities.
How similar studies have performed: Previous research has shown promising results in understanding centrosome function and its implications in various diseases, indicating that this approach is building on established knowledge.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Woodruff, Jeffrey B — Ut Southwestern Medical Center
- Study coordinator: Woodruff, Jeffrey B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.