Understanding how centrosomes are regulated in cells
Post-transcriptional mechanisms of centrosome regulation
This study is looking at how a type of genetic material called mRNA helps control tiny structures in our cells that are important for cell division, which could help us understand conditions like microcephaly and cancer better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11174028 on NIH RePORTER |
What this research studies
This research investigates the role of mRNA in the regulation of centrosomes, which are crucial for cell division and organization. The study aims to uncover how mRNA is localized to centrosomes and the regulatory functions of specific RNA-binding proteins. By using a genetically tractable model, the research will explore the dynamic changes in centrosome composition and organization during the cell cycle. This work is particularly relevant for understanding conditions like microcephaly and cancer, where centrosome dysfunction plays a significant role.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with congenital microcephaly or those affected by cancers associated with centrosome dysfunction.
Not a fit: Patients with conditions unrelated to centrosome regulation or those not experiencing developmental delays or cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the causes of microcephaly and cancer, potentially informing future treatments.
How similar studies have performed: While the specific role of mRNA in centrosome regulation is less explored, related research has shown success in understanding centrosome dysfunction in various diseases.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Lerit, Dorothy a — Emory University
- Study coordinator: Lerit, Dorothy a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.