Understanding how centrosomes are regulated in cells
Post-transcriptional mechanisms of centrosome regulation
This study is looking at how a type of genetic material called mRNA helps control tiny structures in our cells that are important for cell division, which could help us understand conditions like microcephaly and cancer better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10877083 on NIH RePORTER |
What this research studies
This research investigates the role of mRNA in the regulation of centrosomes, which are critical for cell division and function. The study aims to uncover how mRNA is localized to centrosomes and the regulatory roles of specific RNA-binding proteins. By using a genetically tractable model, the research will explore the functions of mRNA at centrosomes, which may have implications for conditions like microcephaly and cancer. This work seeks to fill gaps in our understanding of centrosome dynamics and their impact on cellular processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with congenital birth defects like microcephaly or those affected by cancers linked to centrosome dysfunction.
Not a fit: Patients with conditions unrelated to centrosome regulation or those not affected by microcephaly or cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the causes of microcephaly and cancer, potentially informing future treatments.
How similar studies have performed: While centrosome regulation is a well-studied area, the specific focus on mRNA localization and its functional implications is relatively novel and has not been extensively tested.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Lerit, Dorothy a — Emory University
- Study coordinator: Lerit, Dorothy a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.