Understanding how centromeres maintain chromosome stability
Maintaining the integrity of a genome
This study looks at how a special protein called cohesin helps keep our chromosomes stable during cell division, which is important for preventing health problems like cancer and issues with aging, and it’s designed for anyone interested in understanding how our cells work.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stowers Institute for Medical Research NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project ID | NIH-10884322 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms by which centromeres contribute to the stability of chromosomes, which is crucial for preventing genome instability. It focuses on the cohesin complex, a protein that plays a key role in ensuring accurate chromosome segregation during cell division. By examining how cohesin operates at individual human centromeres, the research aims to create a detailed model of centromeric cohesion and its impact on chromosome stability. This could lead to insights into the origins of various health issues, including cancer and reproductive aging.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of cancer or those experiencing reproductive aging issues.
Not a fit: Patients with stable genomes and no history of chromosomal abnormalities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating conditions related to genome instability, such as cancer.
How similar studies have performed: Previous research has shown promising results in understanding chromosomal stability through similar molecular approaches, indicating a potential for success in this area.
Where this research is happening
Kansas City, United States
- Stowers Institute for Medical Research — Kansas City, United States (Active)
Researchers
- Principal investigator: Gerton, Jennifer L — Stowers Institute for Medical Research
- Study coordinator: Gerton, Jennifer L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.