Understanding how centromeres evolve and affect reproduction in mammals
R35 Investigating rapidly evolving centromeres and their role in the reproductive isolation in mammals
This study looks at how certain parts of our chromosomes, called centromeres, change over time in different groups of house mice, helping us understand how these changes might relate to issues like infertility and chromosome disorders that can affect people.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10863933 on NIH RePORTER |
What this research studies
This research investigates the evolution of centromeres, which are crucial for proper chromosome segregation during cell division. By studying house mouse lineages that are geographically separated and partially reproductively isolated, the research aims to understand how differences in centromeric proteins and satellite DNA contribute to lineage separation. The approach involves advanced genomic techniques to analyze these evolutionary changes and their implications for reproductive isolation. Patients may benefit from insights into genetic factors affecting infertility and chromosomal disorders.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals experiencing infertility or those with known chromosomal disorders.
Not a fit: Patients who do not have infertility issues or chromosomal abnormalities may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of genetic factors that contribute to infertility and chromosomal disorders in humans.
How similar studies have performed: Other research has shown success in understanding evolutionary genetics and its implications for reproductive health, suggesting that this approach may yield valuable insights.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Thakur, Jitendra — Emory University
- Study coordinator: Thakur, Jitendra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.