Understanding how centromeres are formed and inherited in cells
Molecular Basis of Centromere Specification and Inheritance
This study is looking at a part of our cells called the centromere, which helps cells divide correctly, and it's trying to understand how mistakes in this process can lead to health issues like cancer and Down syndrome, so that we can find better ways to help patients in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10753511 on NIH RePORTER |
What this research studies
This research investigates the centromere, a crucial part of chromosomes that ensures proper cell division. By studying the molecular mechanisms that govern centromere specification and inheritance, the project aims to uncover how errors in this process can lead to conditions like cancer and Down syndrome. The research focuses on a specific histone variant, CENP-A, which plays a key role in centromere function and is regulated throughout the cell cycle. Patients may benefit from insights gained into how centromere misregulation contributes to disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by cancers or genetic conditions like Down syndrome that are linked to chromosome missegregation.
Not a fit: Patients with conditions unrelated to chromosomal abnormalities or centromere function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for cancers and genetic disorders associated with aneuploidy.
How similar studies have performed: Previous research has shown that understanding centromere biology can lead to significant advancements in cancer treatment and genetic disorder management.
Where this research is happening
New York, United States
- New York University — New York, United States (Active)
Researchers
- Principal investigator: Li, Fei — New York University
- Study coordinator: Li, Fei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.