Understanding how centromeres affect chromosome stability and birth defects
Centromere Function and Dicentric Chromosome Stability
This study is looking at how special parts of our chromosomes, called centromeres, affect the stability of chromosomes that have two centromeres, which can cause health problems like birth defects and cancer, and it aims to help us understand these issues better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10413900 on NIH RePORTER |
What this research studies
This research investigates the role of centromeres in chromosome stability, particularly focusing on dicentric chromosomes, which have two centromeres. These abnormal chromosomes can lead to various health issues, including birth defects and cancer. The researchers have developed experimental systems to create and study these dicentric chromosomes in a lab setting, allowing them to explore how these chromosomes behave during cell division. By understanding the mechanisms behind chromosome stability, the research aims to uncover new insights into genetic disorders and cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with congenital abnormalities or cancers linked to chromosomal instability.
Not a fit: Patients with conditions unrelated to chromosomal abnormalities or those without genetic predispositions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for congenital abnormalities and cancers associated with chromosomal defects.
How similar studies have performed: Previous research has shown that understanding centromere function can lead to significant insights into chromosomal behavior, suggesting that this approach has potential for success.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Sullivan, Beth a — Duke University
- Study coordinator: Sullivan, Beth a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.