Understanding how centrioles help form cilia and flagella during development
Generation of Diverse Centrosomes, Cilia and Flagellae During Development
This study is looking at how tiny structures called centrioles help build important hair-like parts of cells, like cilia and flagella, using fruit flies to understand how certain proteins work together in different types of cells, including those that help with sensing and reproduction.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California Institute of Technology NIH-funded |
| Lab location | 1 site (Pasadena, United States) |
| Project ID | NIH-10796826 on NIH RePORTER |
What this research studies
This research investigates the role of centrioles in the development of cilia and flagella, which are essential for various cellular functions. By using the fruit fly Drosophila, the study examines how specific proteins interact to regulate the assembly and function of centrioles in different cell types, including those that form sensory cilia and sperm. The research employs molecular and structural biology techniques to explore these interactions and their implications for cell development and function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions linked to cilia and flagella abnormalities, such as certain genetic disorders or cancers.
Not a fit: Patients with conditions unrelated to cilia or centriole function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cellular development and potential treatments for diseases related to cilia and flagella dysfunction.
How similar studies have performed: While the specific approach using Drosophila is novel, similar studies have shown success in understanding centriole function and its implications in human health.
Where this research is happening
Pasadena, United States
- California Institute of Technology — Pasadena, United States (Active)
Researchers
- Principal investigator: Glover, David M — California Institute of Technology
- Study coordinator: Glover, David M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.