Understanding how centrioles form microtubules
Molecular mechanisms of centriolar triplet microtubule formation
This study is looking at how certain proteins help build and maintain tiny structures in our cells called centrioles, which are important for cell function and can be linked to diseases like cancer, and it aims to help us understand these connections better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10878981 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms behind the formation of centriolar triplet microtubules, which are essential for the structure and function of centrioles and cilia in cells. By examining specific proteins like delta-tubulin and epsilon-tubulin, the study aims to uncover how these components contribute to the stability and integrity of centrioles. This knowledge could lead to insights into various diseases linked to centriole dysfunction, such as cancer and ciliopathies. The research employs advanced molecular biology techniques to analyze the interactions and functions of these proteins in cellular contexts.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by diseases related to centriole dysfunction, such as certain cancers or ciliopathies.
Not a fit: Patients with conditions unrelated to centriole or cilium function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases associated with centriole and cilium dysfunction.
How similar studies have performed: Other research has shown promising results in understanding centriole function and its implications in disease, suggesting that this approach has the potential for significant findings.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Wang, Jennifer Tong — Washington University
- Study coordinator: Wang, Jennifer Tong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.