Understanding how centrioles duplicate and grow
Characterizing the molecular mechanisms of centriole duplication and elongation
['FUNDING_OTHER'] · UNIVERSITY OF ARIZONA · NIH-11085521
This study is looking at how tiny structures in our cells, called centrioles, grow and duplicate, which is important for cell division, using fruit flies to help us learn more about the proteins involved, and it could help us understand diseases like cancer better.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ARIZONA (nih funded) |
| Locations | 1 site (TUCSON, UNITED STATES) |
| Trial ID | NIH-11085521 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular mechanisms behind the duplication and elongation of centrioles, which are essential structures in cells that help organize cell division. Using the fruit fly Drosophila as a model, the study aims to uncover how centrioles are regulated during the cell cycle, particularly focusing on the role of specific proteins like Polo-like kinase 4. By employing advanced imaging and genomic techniques, researchers will analyze the proteins involved in centriole function and their interactions. This work could provide insights into the causes of various diseases, including cancer and congenital defects, by understanding how errors in cell division occur.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to cell division abnormalities, such as certain cancers or congenital malformations.
Not a fit: Patients with unrelated health issues or those not affected by cell division disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating diseases related to cell division errors, such as cancer and birth defects.
How similar studies have performed: Other research has shown promising results in understanding centriole function and its implications in diseases, indicating that this area of study is both relevant and potentially impactful.
Where this research is happening
TUCSON, UNITED STATES
- UNIVERSITY OF ARIZONA — TUCSON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROGERS, GREGORY CHARLES — UNIVERSITY OF ARIZONA
- Study coordinator: ROGERS, GREGORY CHARLES
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: cancer cell, Cancers