Understanding how centrioles and centrosomes function in cells
Centriole assembly and function for centrosome and cilia biology
['FUNDING_OTHER'] · UNIVERSITY OF COLORADO DENVER · NIH-11051771
This study is looking at how tiny structures in our cells, called centrioles and centrosomes, help keep our tissues healthy and function properly, especially in conditions like cancer and Down syndrome, so we can better understand how cells work and what might go wrong.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-11051771 on ClinicalTrials.gov |
What this research studies
This research investigates the role of centrioles and centrosomes in organizing cells and maintaining tissue health. It focuses on how these structures control the microtubule network, which is essential for various cellular processes such as signaling, cell division, and movement. The research aims to uncover the mechanisms behind centriole duplication and their impact on cilia function, particularly in conditions like cancer and Down syndrome. By exploring these processes, the study seeks to enhance our understanding of cellular behavior and its implications for health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals affected by cancer or conditions related to chromosome 21 trisomy, such as Down syndrome.
Not a fit: Patients with unrelated genetic or cellular disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cellular dysfunctions associated with cancer and genetic disorders, potentially informing future treatments.
How similar studies have performed: While the specific mechanisms of centriole function are still being explored, previous research has shown promising results in understanding cellular organization and its implications for disease.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PEARSON, CHAD G — UNIVERSITY OF COLORADO DENVER
- Study coordinator: PEARSON, CHAD G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: cancer cell, Cancers