Understanding how cellular stress leads to aging and disease
A novel cilium-to-nucleus axis promotes cellular senescence
This study is looking at how stressed-out cells that stop dividing can affect aging and health, and it’s for anyone interested in understanding how we might improve health and longevity by targeting these cells, especially in conditions like cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11041101 on NIH RePORTER |
What this research studies
This research investigates the role of cellular senescence, a process where cells stop dividing due to stress, in aging and age-related diseases. It explores how primary cilia, small cellular structures, help cells respond to their environment and how their dysfunction can lead to various health issues. By studying human cells under stress, the research aims to uncover mechanisms that could lead to new treatments for aging-related conditions and cancer. The approach includes genetic and pharmacological methods to target and potentially eliminate senescent cells, which may improve health and longevity.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related health issues or those at risk of developing such conditions.
Not a fit: Patients who are not experiencing age-related diseases or are younger individuals may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent or treat age-related diseases and improve overall health in older adults.
How similar studies have performed: Previous research has shown that targeting cellular senescence can improve health outcomes in animal models, suggesting a promising avenue for human therapies.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Hu, Jinghua — Mayo Clinic Rochester
- Study coordinator: Hu, Jinghua
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.