Understanding how cellular signals are regulated in cancer
Molecular and Cellular Dynamics in Mammalian Signal Transduction
This study is looking at how a protein called ERK2 works in our cells and how it can be turned on or off, which could help us understand cancer better and find new ways to treat it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado NIH-funded |
| Lab location | 1 site (Boulder, UNITED STATES) |
| Project ID | NIH-11012195 on NIH RePORTER |
What this research studies
This research investigates the mechanisms of allosteric regulation in a key protein involved in cell signaling, known as ERK2. By examining how the movements of this protein influence its activation and the cellular responses to various inhibitors, the research aims to uncover new insights into cancer biology. Additionally, it explores how different levels of ERK signaling affect cellular behavior, which could lead to better therapeutic strategies for cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cancers that involve dysregulated ERK signaling.
Not a fit: Patients with cancers unrelated to ERK signaling or those with advanced disease stages may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer therapies by providing a deeper understanding of how to manipulate cell signaling pathways.
How similar studies have performed: Other research has shown promising results in understanding protein signaling mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Boulder, UNITED STATES
- University of Colorado — Boulder, United States (Active)
Researchers
- Principal investigator: Ahn, Natalie G. — University of Colorado
- Study coordinator: Ahn, Natalie G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.