Understanding how cellular signals affect cell growth and metabolism
Official title: Ubiquitin and Metabolite Signaling
Funded at University of California-Irvine · NIH-11042723 · Data updated 2026-11-12
This study is looking at how cells, like those in our bodies, detect changes in their environment and energy levels, focusing on a special signal called ubiquitin, which helps them grow and divide properly; the findings could help us understand age-related diseases and improve cancer treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | March 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $605,891 |
| NIH project number | 5R35GM148350-03 |
| Project ID | NIH-11042723 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by age-related diseases or conditions that involve metabolic dysregulation.
✕Less likely to help
Patients with acute conditions unrelated to metabolic signaling or age-related diseases may not benefit from this research.
What this research studies
This research investigates how cells sense and respond to metabolic and environmental signals, focusing on the role of ubiquitin signaling in these processes. By studying both yeast and mammalian cell models, the project aims to uncover the mechanisms by which cells communicate their metabolic states to regulate the cell cycle. The research will explore how different types of ubiquitin chains are recognized and how specific proteins interact with these signals to influence cell growth and proliferation. This work could provide insights into age-related diseases and cancer therapies.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating age-related diseases and improving cancer therapies.
How similar studies have gone: Previous research has shown success in understanding ubiquitin signaling in yeast models, suggesting potential for similar insights in mammalian systems.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Kaiser, Peter — University of California-Irvine
- Study coordinator: Kaiser, Peter
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.