Understanding how cellular processes affect blood vessel changes in pulmonary arterial hypertension.
Regulation of UPRmt activation in the development of pulmonary vascular remodeling in PAH
This study is looking at how changes in blood vessels happen in people with pulmonary arterial hypertension (PAH) and aims to find new ways to treat the condition by understanding the underlying processes better.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10897905 on NIH RePORTER |
What this research studies
This research investigates the cellular mechanisms that lead to changes in blood vessels in patients with pulmonary arterial hypertension (PAH). It focuses on how certain signaling pathways and mitochondrial functions contribute to the disease's progression. By studying these processes in both human cells and model organisms, the research aims to identify potential therapeutic targets that could help alleviate the vascular abnormalities associated with PAH. Patients may benefit from insights gained that could lead to new treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pulmonary arterial hypertension.
Not a fit: Patients with other forms of pulmonary hypertension or those without a diagnosis of pulmonary arterial hypertension may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve outcomes for patients with pulmonary arterial hypertension.
How similar studies have performed: Previous research has shown promising results in understanding cellular signaling pathways in similar conditions, suggesting potential for success in this area.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Lockett, Angelia Denise — Indiana University Indianapolis
- Study coordinator: Lockett, Angelia Denise
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.