Understanding how cellular aging affects egg development
Official title: Cellular rejuvenation during oogenesis
Funded at Icahn School of Medicine at Mount Sinai · NIH-10864188 · Data updated 2026-11-12
This study is looking at how a part of our cells called the nuclear pore complex affects aging and the development of female reproductive cells, using fruit flies to see if a process that recycles damaged cell parts can help keep these cells healthy, which could lead to better understanding of reproductive health for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 15, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $387,068 |
| NIH project number | 1R56AG082906-01 |
| Project ID | NIH-10864188 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women experiencing age-related fertility challenges or those interested in understanding the biological mechanisms of aging in reproductive cells.
✕Less likely to help
Patients who are not affected by age-related fertility issues or who do not have an interest in reproductive health may not benefit from this research.
What this research studies
This research investigates the role of the nuclear pore complex (NPC) in aging and its impact on the development of oocytes, which are the female reproductive cells. By studying the mechanisms of germline stem cell differentiation into oocytes in fruit flies, the research aims to uncover how damaged cellular components can be rejuvenated during this process. The study will explore whether autophagy, a cellular recycling process, plays a significant role in maintaining the health of these cells as they develop. Patients may benefit from insights gained about cellular aging and reproductive health.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving reproductive health and addressing age-related fertility issues.
How similar studies have gone: Other research has shown promising results in understanding cellular rejuvenation mechanisms, particularly in model organisms, suggesting potential applicability to human health.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Rangan, Prashanth — Icahn School of Medicine at Mount Sinai
- Study coordinator: Rangan, Prashanth
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.