Understanding how cells work and what happens when they are mutated
Deciphering the hierarchical modularity of the mammalian cell through network integration and complex genetic perturbation strategies
This study is looking at how changes in our genes can affect the way our cells work, with the hope of finding new ways to treat diseases, so patients can benefit from better-targeted therapies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10896902 on NIH RePORTER |
What this research studies
This research investigates the complex interactions within mammalian cells and how these interactions change when mutations occur. By using advanced CRISPR techniques, the team aims to identify critical genetic vulnerabilities that could lead to new treatment strategies for diseases. The research combines experimental and computational methods to analyze how genes interact and affect cell survival and proliferation. Patients may benefit from insights gained about the genetic underpinnings of their conditions, potentially leading to targeted therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic mutations that may affect cell function and contribute to disease.
Not a fit: Patients with conditions unrelated to genetic mutations or those not involving cellular dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies for various diseases by identifying genetic vulnerabilities in cells.
How similar studies have performed: Previous research using CRISPR techniques has shown promise in identifying genetic interactions and vulnerabilities, indicating a strong potential for success in this area.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Hart, Glen Traver — University of Tx Md Anderson Can Ctr
- Study coordinator: Hart, Glen Traver
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.