Understanding how cells transport materials to lysosomes
Official title: Membrane trafficking to lysosomes
Funded at University of Colorado · NIH-11080334 · Data updated 2026-11-12
This study is looking at how cells move important materials to lysosomes, which help break down waste, using yeast as a model, to better understand how problems in this process might be connected to genetic diseases and how germs could take advantage of it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado NIH-funded |
| Lab location | 1 site (Boulder, UNITED STATES) |
| Project start | May 4, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $515,004 |
| NIH project number | 5R35GM149202-03 |
| Project ID | NIH-11080334 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic disorders that affect lysosomal function or those interested in understanding cellular processes related to lysosomal trafficking.
✕Less likely to help
Patients with conditions unrelated to lysosomal function or those not affected by genetic disorders may not benefit from this research.
What this research studies
This research investigates the mechanisms by which cells deliver materials to lysosomes, the organelles responsible for breaking down waste and cellular components. Using the budding yeast as a model, the study aims to uncover how various proteins and pathways regulate the trafficking of cell-surface receptors to lysosomes. By exploring these fundamental processes, the research seeks to identify potential links between disruptions in these pathways and genetic diseases, as well as how pathogens may exploit these mechanisms. The findings could provide insights into cellular function and disease mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating genetic diseases linked to lysosomal dysfunction.
How similar studies have gone: Previous research has shown success in understanding cellular trafficking mechanisms in model organisms, indicating that this approach is promising.
Where this research is happening
-
University of Colorado
Boulder, United States Active
Researchers
- Principal investigator: Odorizzi, Charles G — University of Colorado
- Study coordinator: Odorizzi, Charles G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.