Understanding how cells transport materials and repair DNA
Mechanism of cytoskeletal transport and transcription-coupled DNA repair
This study is looking at how cells keep everything organized inside them and fix their DNA, focusing on the tiny structures and motors that help move important materials around, which could help us understand how cells stay healthy and work properly.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10872311 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which cells organize their internal components and repair DNA. It focuses on the role of the microtubule cytoskeleton and molecular motors, particularly dynein and kinesin, in transporting various cellular materials. The study will explore how specific proteins, like Lis1, contribute to the assembly and activation of transport complexes, as well as how ATP-dependent nucleosome remodelers affect chromatin dynamics. By using advanced techniques such as cryo-electron microscopy, the research aims to uncover the intricate processes that ensure cellular function and stability.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals with genetic disorders or conditions that affect cellular transport and DNA repair.
Not a fit: Patients with conditions unrelated to cellular transport or DNA repair mechanisms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cellular transport and DNA repair mechanisms, potentially informing treatments for diseases related to these processes.
How similar studies have performed: Other research has shown success in understanding cellular transport mechanisms, making this study a continuation of established scientific inquiry.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Leschziner, Andres — University of California, San Diego
- Study coordinator: Leschziner, Andres
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.