Understanding how cells transport important materials within neurons
Molecular Mechanisms of Axonal Transport and Organelle Dynamics
['FUNDING_OTHER'] · UNIVERSITY OF PENNSYLVANIA · NIH-11066456
This study is looking at how tiny motors inside nerve cells help move important parts, like energy sources and communication tools, to where they’re needed, which could help us understand problems in diseases like ALS and Charcot-Marie-Tooth disease.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11066456 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which molecular motors transport organelles along the axons of neurons, which are crucial for maintaining cellular health and function. It focuses on how these motors, regulated by specific proteins, ensure the delivery of essential components like mitochondria and synaptic vesicles to their proper locations within the neuron. By using advanced imaging techniques and laboratory experiments, the research aims to uncover the dynamics of this transport process and its implications for neurodegenerative diseases. Patients may benefit from insights gained into how disruptions in this transport system contribute to conditions like amyotrophic lateral sclerosis and Charcot-Marie-Tooth disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with neurodegenerative diseases such as amyotrophic lateral sclerosis or Charcot-Marie-Tooth disease.
Not a fit: Patients with acute neurological injuries or conditions unrelated to axonal transport may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for neurodegenerative diseases by improving our understanding of neuronal transport mechanisms.
How similar studies have performed: Previous research has shown promising results in understanding axonal transport mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HOLZBAUR, ERIKA L — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: HOLZBAUR, ERIKA L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Amyotrophic Lateral Sclerosis Motor Neuron Disease