Understanding how cells transport important materials for growth and survival.
Official title: Increasing the Complexity of Microtubule-based transport: Cargo adaptors and Hitchhiking on Vesicles.
Funded at University of Vermont & St Agric College · NIH-10933418 · Data updated 2026-11-12
This study is looking at how cells move important materials around, which is especially important for people with Parkinson's disease, to better understand how these processes work and what might go wrong in neurodegenerative disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Vermont & St Agric College NIH-funded |
| Lab location | 1 site (Burlington, United States) |
| Project start | September 22, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $390,000 |
| NIH project number | 5R35GM150857-02 |
| Project ID | NIH-10933418 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by neurodevelopmental and neurodegenerative disorders, particularly those with conditions linked to defects in cellular transport.
✕Less likely to help
Patients with conditions unrelated to cellular transport mechanisms or those not experiencing neurodegenerative disorders may not benefit from this research.
What this research studies
This research investigates the mechanisms by which cells transport essential materials, such as organelles and vesicles, along microtubules, which are critical for cell growth and survival. It focuses on two main transport modes: the cargo adaptor mode, where specific proteins help load and unload cargo, and organelle hitchhiking, where vesicles assist in moving organelles. By studying how these processes are regulated, particularly in relation to a phosphorylation site linked to Parkinson's disease, the research aims to uncover new insights into cellular function and the underlying causes of neurodegenerative disorders.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating neurodegenerative diseases by improving our understanding of cellular transport mechanisms.
How similar studies have gone: Previous research has shown success in understanding cellular transport mechanisms, but this specific approach focusing on the phosphorylation site related to Parkinson's disease is relatively novel.
Where this research is happening
-
University of Vermont & St Agric College
Burlington, United States Active
Researchers
- Principal investigator: Salogiannis, John — University of Vermont & St Agric College
- Study coordinator: Salogiannis, John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.