Understanding How Cells Transport Genetic Messages
Molecular Basis of mRNA Export
This project explores how our cells move important genetic instructions from the cell's control center to where they are needed.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California Institute of Technology NIH-funded |
| Lab location | 1 site (Pasadena, United States) |
| Project ID | NIH-11137673 on NIH RePORTER |
What this research studies
Our cells store genetic information, like blueprints, inside a central compartment called the nucleus. For these instructions to be used, they must travel out of the nucleus through tiny gateways known as nuclear pore complexes (NPCs). This project aims to uncover the detailed structure and function of these NPCs in human cells. By understanding how these complex gateways work, we can gain fundamental insights into how cells control the flow of genetic information. This basic knowledge is essential for understanding many biological processes and diseases.
Who could benefit from this research
Good fit: This foundational biological work does not directly involve patients, but future research stemming from it could benefit individuals with conditions related to cellular transport or viral infections.
Not a fit: Patients seeking immediate treatment or direct clinical intervention will not find direct benefit from this basic science project.
Why it matters
Potential benefit: A deeper understanding of how cells transport genetic messages could help us understand and potentially address many diseases where this fundamental process goes wrong.
How similar studies have performed: Researchers have made significant progress in understanding parts of the nuclear pore complex, and this project builds upon two decades of work using advanced imaging and biochemical techniques.
Where this research is happening
Pasadena, United States
- California Institute of Technology — Pasadena, United States (Active)
Researchers
- Principal investigator: Hoelz, Andre — California Institute of Technology
- Study coordinator: Hoelz, Andre
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.