Understanding how cells transition from mitosis to meiosis
Regulatory mechanisms of meiotic entry and progression
This study is looking at how cells divide to create sperm and eggs, focusing on the important steps that help control this process, and it's using mice to learn more about the roles of certain proteins in making sure everything works properly.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers, the State Univ of N.j. NIH-funded |
| Lab location | 1 site (Piscataway, United States) |
| Project ID | NIH-10916190 on NIH RePORTER |
What this research studies
This research investigates the critical process of meiosis, where diploid cells transform into haploid gametes necessary for reproduction. It focuses on the genetic and molecular mechanisms that regulate this transition, particularly how gene expression and chromosome behaviors are controlled. Using mouse models, the study explores two key pathways that influence meiosis, aiming to uncover the roles of specific proteins in this process. By mapping protein-RNA interactions, the research seeks to clarify how these regulatory mechanisms function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing infertility or recurrent miscarriages due to chromosomal abnormalities.
Not a fit: Patients with infertility not related to chromosomal issues or those who have already achieved successful pregnancies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for infertility and genetic disorders related to aneuploidy.
How similar studies have performed: While the mechanisms of meiosis have been studied, this research aims to explore novel pathways that have not been extensively tested in humans.
Where this research is happening
Piscataway, United States
- Rutgers, the State Univ of N.j. — Piscataway, United States (Active)
Researchers
- Principal investigator: Jain, Devanshi — Rutgers, the State Univ of N.j.
- Study coordinator: Jain, Devanshi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.