Understanding how cells transition from a resting state to permanent aging
Official title: Defining the transition from deep quiescence to senescence
Funded at University of Colorado · NIH-11116837 · Data updated 2026-11-12
This study is looking at how cells can either take a break or age permanently, and it wants to find out what makes them different, especially since some cells that take a break might not respond well to cancer treatments.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado NIH-funded |
| Lab location | 1 site (Boulder, UNITED STATES) |
| Project start | June 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $41,346 |
| NIH project number | 5F31CA284877-02 |
| Project ID | NIH-11116837 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are cancer patients who have experienced treatment and may have quiescent cancer cells that contribute to drug resistance.
✕Less likely to help
Patients with non-cancerous conditions or those who have not undergone cancer treatment may not benefit from this research.
What this research studies
This research investigates the different states of cell-cycle exit, specifically focusing on how cells can either enter a temporary resting state (quiescence) or a permanent aging state (senescence). It aims to identify the molecular characteristics that differentiate these states and how cells that remain quiescent for extended periods may become resistant to cancer treatments. By utilizing advanced single-cell assays and biomarkers, the study seeks to uncover the mechanisms that control these transitions, which could have significant implications for cancer therapy.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer treatments by targeting drug-resistant cells more effectively.
How similar studies have gone: Previous research has shown promising results in understanding cell cycle dynamics and their implications for cancer treatment, indicating that this approach has potential for success.
Where this research is happening
-
University of Colorado
Boulder, United States Active
Researchers
- Principal investigator: Fernandez, Brianna — University of Colorado
- Study coordinator: Fernandez, Brianna
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.