Understanding how cells transition from a resting state to permanent aging
Defining the transition from deep quiescence to senescence
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF COLORADO · NIH-11116837
This study is looking at how cells can either take a break or age permanently, and it wants to find out what makes them different, especially since some cells that take a break might not respond well to cancer treatments.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO (nih funded) |
| Locations | 1 site (Boulder, UNITED STATES) |
| Trial ID | NIH-11116837 on ClinicalTrials.gov |
What this research studies
This research investigates the different states of cell-cycle exit, specifically focusing on how cells can either enter a temporary resting state (quiescence) or a permanent aging state (senescence). It aims to identify the molecular characteristics that differentiate these states and how cells that remain quiescent for extended periods may become resistant to cancer treatments. By utilizing advanced single-cell assays and biomarkers, the study seeks to uncover the mechanisms that control these transitions, which could have significant implications for cancer therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients who have experienced treatment and may have quiescent cancer cells that contribute to drug resistance.
Not a fit: Patients with non-cancerous conditions or those who have not undergone cancer treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer treatments by targeting drug-resistant cells more effectively.
How similar studies have performed: Previous research has shown promising results in understanding cell cycle dynamics and their implications for cancer treatment, indicating that this approach has potential for success.
Where this research is happening
Boulder, UNITED STATES
- UNIVERSITY OF COLORADO — Boulder, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FERNANDEZ, BRIANNA — UNIVERSITY OF COLORADO
- Study coordinator: FERNANDEZ, BRIANNA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.