Understanding how cells take in materials through a specific process called clathrin-mediated endocytosis
Modeling and analysis of the mechanochemical processes that govern clathrin-mediated endocytosis
This study is looking at how cells take in materials from their environment, especially focusing on a process called clathrin-mediated endocytosis, to better understand how this works and how it can help create new medicines for diseases like cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10746802 on NIH RePORTER |
What this research studies
This research investigates the process by which cells absorb materials from their surroundings, focusing on clathrin-mediated endocytosis (CME). It aims to understand the mechanical and biochemical factors that influence this process, particularly how membrane tension and interactions with the cytoskeleton affect CME. By utilizing advanced imaging technologies and computational modeling, the research seeks to create a predictive framework that can help in developing nanomedicines. This work is crucial as defects in endocytosis are linked to various diseases, including cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to defective endocytosis, particularly those with cancer or neurodegenerative diseases.
Not a fit: Patients with conditions unrelated to endocytosis or those who do not have cancer or neurodegenerative diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for drug delivery and treatment of diseases related to endocytosis, such as cancer.
How similar studies have performed: Other research has shown success in understanding cellular processes through similar mechanistic and computational approaches, indicating that this research builds on established methodologies.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Rangamani, Padmini — University of California, San Diego
- Study coordinator: Rangamani, Padmini
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.