Understanding how cells stop dividing and enter a resting state
Equipment supplement: Probing the flexibility of G0
This study is looking at how cells decide when to take a break from dividing, especially during times like healing or when nutrients are low, to help us understand how these resting cells play a role in growing and repairing our tissues and organs.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11034880 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that control the cell cycle, particularly focusing on the G0 phase where cells enter a non-dividing state. It aims to uncover how cells decide to enter or exit this phase during development and in response to various signals such as tissue damage or nutrient availability. By studying the different states of G0, the research seeks to understand the physiological roles of quiescent cells and their importance in tissue and organ development. This could involve advanced techniques to analyze cell behavior and signaling pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to cell cycle regulation, such as certain cancers or age-related disorders.
Not a fit: Patients with conditions unrelated to cell cycle regulation or those who are not experiencing issues with cell proliferation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cell behavior that may improve treatments for cancers and age-related diseases.
How similar studies have performed: Previous research has shown promising results in understanding cell cycle regulation, but this specific focus on the G0 phase is relatively novel.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Buttitta, Laura a — University of Michigan at Ann Arbor
- Study coordinator: Buttitta, Laura a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.