Understanding how cells stop dividing and enter a resting state
Official title: Equipment supplement: Probing the flexibility of G0
Funded at University of Michigan at Ann Arbor · NIH-11034880 · Data updated 2026-11-12
This study is looking at how cells decide when to take a break from dividing, especially during times like healing or when nutrients are low, to help us understand how these resting cells play a role in growing and repairing our tissues and organs.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | August 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $225,000 |
| NIH project number | 3R35GM149273-02S1 |
| Project ID | NIH-11034880 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to cell cycle regulation, such as certain cancers or age-related disorders.
✕Less likely to help
Patients with conditions unrelated to cell cycle regulation or those who are not experiencing issues with cell proliferation may not benefit from this research.
What this research studies
This research investigates the mechanisms that control the cell cycle, particularly focusing on the G0 phase where cells enter a non-dividing state. It aims to uncover how cells decide to enter or exit this phase during development and in response to various signals such as tissue damage or nutrient availability. By studying the different states of G0, the research seeks to understand the physiological roles of quiescent cells and their importance in tissue and organ development. This could involve advanced techniques to analyze cell behavior and signaling pathways.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cell behavior that may improve treatments for cancers and age-related diseases.
How similar studies have gone: Previous research has shown promising results in understanding cell cycle regulation, but this specific focus on the G0 phase is relatively novel.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Buttitta, Laura a — University of Michigan at Ann Arbor
- Study coordinator: Buttitta, Laura a
Related research
Other NIH-funded projects on the same topics.
-
Expanding genetic testing for cancer risk in patients and families
This study is working to make it easier for cancer patients in Michigan to get genetic testing for cancer risk by improving how doctors gather family history and assess genetic risks, so that more people can receive the important evaluations they need.
-
HEARTS hypertension and diabetes care in Guatemala
This grant tests how well the HEARTS primary care model works in Guatemala to improve blood pressure and blood sugar control for patients.
-
Why the retina can sometimes heal itself and how we might help it heal
This NIH grant explores how inflammation and neural cells interact in the zebrafish retina to understand retinal neuron death and regeneration, with potential implications for human vision.
-
Integrated Heart Health: A HEARTS-based approach to hypertension and diabetes in Guatemala
A study tests a team-based, stepwise care model to improve blood pressure and blood sugar control for people with both hypertension and diabetes in Guatemala.
-
Understanding how work exposures and genes influence ALS risk
A study is building a long-term group of people at higher risk for ALS to see how their jobs, exposures at work, and genes together affect if and when the disease might develop.
-
An integrated mobile health program to reduce SAVA and mental health problems among female sex workers in Kenya
A new mobile health program aims to help female sex workers in Kenya avoid substance abuse, violence, HIV, and depression by delivering group therapy, online resources, and a peer discussion space.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.