Understanding how cells stop dividing and enter a resting state
Official title: Probing the flexibility of G0
Funded at University of Michigan at Ann Arbor · NIH-10890583 · Data updated 2026-11-12
This study is looking at how cells take breaks from dividing and what makes them start dividing again, which is important for keeping our tissues healthy and could help us understand diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | August 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $343,544 |
| NIH project number | 5R35GM149273-02 |
| Project ID | NIH-10890583 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to abnormal cell growth or those interested in the biological processes of aging.
✕Less likely to help
Patients with stable, non-cancerous conditions that do not involve cell cycle dysregulation may not benefit from this research.
What this research studies
This research investigates the mechanisms that control the cell cycle, particularly focusing on the G0 phase where cells enter a non-dividing state. It aims to uncover how cells decide to stop dividing during development and how they can re-enter the cell cycle in response to various signals. By studying different states of G0, the research seeks to understand the physiological roles of quiescent cells and their importance in tissue health and regeneration. This could provide insights into how disruptions in these processes may lead to diseases such as cancer.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating cancers and other conditions related to cell cycle regulation.
How similar studies have gone: Previous research has shown promising results in understanding cell cycle regulation, but this specific focus on the G0 phase is relatively novel.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Buttitta, Laura a — University of Michigan at Ann Arbor
- Study coordinator: Buttitta, Laura a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.