Understanding how cells stick together and signal for health and disease
Project 2- Mechanistic Role of Talin in Cellular Signaling
This work aims to understand how certain cell proteins, called integrins, become active and send signals, which is important for conditions like blood clotting and stroke.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11124008 on NIH RePORTER |
What this research studies
Our cells use special receptors called integrins to stick to their surroundings and communicate, which is vital for many body processes. When integrins don't work correctly, it can lead to problems like issues with blood vessel formation, blood clots, or even stroke. This project focuses on a key protein called talin, which helps activate integrins. We are exploring how talin works to turn on integrins and connect them to the cell's internal structure, aiming to uncover new details about these fundamental processes.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit individuals affected by conditions involving cell adhesion, such as blood clotting disorders or stroke, in the long term.
Not a fit: Patients seeking immediate treatment or direct clinical intervention would not receive benefit from this basic science project.
Why it matters
Potential benefit: If successful, this research could lead to a deeper understanding of diseases related to cell adhesion and signaling, potentially paving the way for new treatments for conditions like thrombosis and stroke.
How similar studies have performed: Integrins have been extensively studied for decades, but this project explores new aspects of their activation mechanism, challenging existing beliefs.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Qin, Jun — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Qin, Jun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.